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The Toxin hypothesis (n.) Jung returned to late in life: emotion exceeding the capacity of brain-cells might cause a local organic disintegration, a view encouraged by experience with mescalin.
The Toxin hypothesis (n.) was Jung's tentative 1906 guess that the affect in dementia praecox might trigger metabolic poisons injuring the brain, so the last complex "coagulates" and further development halts; a primary physical change could not be excluded.