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A lack of cats led to a rat infestation which led to the spread of the plague.

During WWII, Japan bombed China with fleas infected with the bubonic plague.
Biological warfare was used among the Mongols who would catapult the dead bodies of soldiers infected by the bubonic plague over city walls during sieges.
During the great plague in London (1655), people would fart in jars, store them, and later inhale them to ward off disease.
The Black Death is estimated to have killed more than 100 million people in the 13th century.